Modern Psychological Studies
University of Tennessee at Chattanooga
Place of Publication
The effects of chronic oral administration of a standardized Ginkgo biloba extract (GBE) on the performance of two classical memory tasks was investigated. Long-Evans rats, 3 and 16 months of age, received daily doses of diets with or without GBE (100 mg/kg) for a period of 6 weeks before testing and throughout the experiment. A 2 x 2 (Age x Treatment) ANOVA indicated that GBE treatment prevented learning on a radial maze task as measured by number of days to criterion, F(1, 28) = 5.73, p < .05. A 2 x 2 x 19 (Age x Treatment x Day) ANOVA was used to analyze the number of correct responses from Days 1 to 19. The results showed an interaction between Age and Treatment F(1, 28) = 6.34, p <. 05; namely young treated rats performed worse than other groups. Analysis of response frequency by a 2 x 2 (Age x Treatment) ANOVA revealed a significant interaction F(1, 28) = 4.41, p < .05, and a subsequent post hoc test indicated that the young treatment group responded notably more than the old groups. Measured performance on a one-way passive avoidance task indicated that neither treatment nor age had an effect. The results suggest that at the prescribed dose level and duration, GBE impairs performance on a radial maze task, particularly in young rats.
BF1 .M63 v. 3 no. 2 1995
"The effects of a standardized ginkgo bilboa extract on learning in aged and young rats,"
Modern Psychological Studies: Vol. 3
, Article 9.
Available at: http://scholar.utc.edu/mps/vol3/iss2/9