Committee Chair

Yang, Li

Committee Member

Winters, Katherine; Kandah, Farah

Department

Dept. of Computer Science and Engineering

College

College of Engineering and Computer Science

Publisher

University of Tennessee at Chattanooga

Place of Publication

Chattanooga (Tenn.)

Abstract

Substantial health disparities exist between African Americans and Caucasians in the United States. Copy number variations (CNVs) are one form of human genetic variations that have been linked with complex diseases and often occur at different frequencies among African Americans and Caucasian populations. In this study, we aimed to investigate whether CNVs with differential population frequencies can contribute to health disparities from the perspective of gene networks. We inferred network clusters from two different human gene/protein networks. We then evaluated each network cluster for the occurrences of known pathogenic genes and genes located in CNVs with different population frequencies, and used false discovery rates (FDRs) to rank network clusters. This approach let us identify five clusters enriched with known pathogenic genes and with genes located in CNVs with different frequencies between African Americans and Caucasians. These clustering patterns predict four candidate causal population-specific CNVs that play potential roles in health disparities.

Acknowledgments

I would like to express my deepest gratitude to my advisor, Dr. Li Yang, for her thoughtful guidance, warm encouragement, great patience, and financial support during the whole period of my research. I appreciate her vast knowledge and skills, and her assistance in writing this thesis. I would like to thank my thesis committee members, Prof. Farah Kandah and Ms. Katherine Winters for their excellent advises and detailed review during the preparation of this thesis. I would also like to thank Prof. Hong Qin at Spelman College, Atlanta, GA, for thoughtful guidance, insightful discussion, correction of my writing, and the help to develop my background in computational biology and genetics.

Degree

M. S.; A thesis submitted to the faculty of the University of Tennessee at Chattanooga in partial fulfillment of the requirements of the degree of Master of Science.

Date

12-2014

Subject

Bioinformatics; Variation (Biology); Human genetics; Genetic disorders

Keyword

Health disparities; Copy Number Variations (CNVs); Network clustering

Document Type

Masters theses

Extent

ix, 47 leaves

Language

English

Rights

Under copyright.

License

http://creativecommons.org/licenses/by-nc-nd/3.0/

Share

COinS