Modern Psychological Studies
University of Tennessee at Chattanooga
Place of Publication
Female Syrian hamsters engage in vaginal scent-marking (VM) to advertise their sexual receptivity. VM is facilitated by estrogen; however, the hormone's mechanism of action is unknown. Classically, estrogen binds to intracellular receptors and promotes gene transcription to eventually affect behavior. Estrogen may non-classically and rapidly affect behavior via binding to membrane localized receptors. In order to determine how estrogen modulates VM, VM levels were examined in 10 female hamsters across several hormone conditions. Levels of VM were assessed across 3 trials in intact, normally-cycling subjects. These trials were repeated following ovariectomy. A final set of trials were conducted in ovariectomized subjects injected with either 113 -estradiol or vehicle and tested 30 minutes following injection. VM frequency significantly decreased after ovariectomy. There was no significant effect, however of 113 -estradiol compared to vehicle injections on VM behavior. These results suggest that estradiol may not regulate vaginal marking via a non-classical mechanism.
BF1 .M63 v. 16 no. 2 2011
Garretson, John T.; Gobbel, Spencer L.; Lewis, Christine M.; Martinez, Luis A.; and Petrulis, Aras
"Examining the rapid non-classical effects of 17 beta estradiol on sexual advertisement behavior of the golden hamster (mesocricetus auratus),"
Modern Psychological Studies: Vol. 16:
2, Article 8.
Available at: https://scholar.utc.edu/mps/vol16/iss2/8