Modern Psychological Studies
Periodical Title
Modern Psychological Studies
Volume
3
Number
1
Page Numbers
pages 47-56
Publisher
University of Tennessee at Chattanooga
Place of Publication
Chattanooga (Tenn.)
Date
1995
Abstract
This study investigated perseverative behavior, attention, and exploratory behaviors via discrete lesions of the rat hippocampal formation. It was hypothesized that lesions which interrupted input to the hippocampus and output to cortical and subcortical regions would induce these behaviors. Forty-four male Long-Evan rats were randomly divided into four treatment groups: cerebral spinal fluid, and three colchicine lesioned groups, 10-COL, 15-COL, and 25-COL. The animals were compared based upon performance in a standard Tmaze to test perseveration. Behaviors were also observed in an activity chamber to measure locomotion, attention, and exploration. Animals in the 25-COL group demonstrated a significant increase in activity and perseveration as well as a decrease in exploration and attention compared to all other groups. Disrupting the convergence of information to the hippocampal formation interferes with output to subcortical and cortical regions, inducing behavioral changes associated with the structures of the hippocampal system.
Subject
Psychology
Discipline
Psychology
Document Type
article
DCMI Type
Text
Extent
10 leaves
Language
English
Call Number
BF1 .M63 v. 3 no. 1 1995
Rights
http://rightsstatements.org/vocab/InC/1.0/
Recommended Citation
Wagoner, David E. Jr. and Israelian, Zhenique M.
(1995)
"Spontaneous alternating behavior, attention, and exploration: the effects of colchicine lesions in the rat hippocaompal formation,"
Modern Psychological Studies: Vol. 3:
No.
1, Article 8.
Available at:
https://scholar.utc.edu/mps/vol3/iss1/8
Department
Dept. of Psychology