Richards, Sean M.
Kovach, Margaret J.; Symes, Steve; Adair, C. David
College of Arts and Sciences
University of Tennessee at Chattanooga
Place of Publication
Infants born below 2,500 grams are classified as low birth w eight. Reduced birth weight has been shown to increase the risk of infant mortality and chronic adulthood diseases. In 2007, Hamilton Country reported 12.0% of live births to be low birth weight, compared to the state average of 9.4%. An excess in utero exposure to cortisol has been linked to restricted fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight centile. A Spearman's rank correlation reported a significant correlation between these two variables (p = 0.024). Additionally, birth weight was significantly different between underweight and obese mothers, married vs. single mothers and black vs. white mothers. These results reinforce the importance of proper 11β-HSD2 expression for optimal fetal growth.
M. S.; A thesis submitted to the faculty of the University of Tennessee at Chattanooga in partial fulfillment of the requirements of the degree of Master of Science.
Birth weight, Low
ix, 58 leaves
Mikelson, Colleen Katherine, "Placental 11b-hydroxysteroid dehydrogenase expression and birth weight in Hamilton County, TN" (2012). Masters Theses and Doctoral Dissertations.